Nevertheless, there may be potential for clinically important alterations of blood levels of co-administered drugs. In a lactation study of 10 women, levels of orally dosed bupropion and its active metabolites were measured in expressed milk. The average daily infant exposure (assuming 150 mL/kg daily consumption) to bupropion and its active metabolites was 2% of the maternal weight-adjusted dose.
How Does This Medication Work?
Call your healthcare provider if your blood pressure increases while taking this medicine. Other formulations/prescriptions of bupropion may be available. Examine the prescription label on your prescription bottle to be sure it is what your doctor has ordered. Ask your doctor or pharmacist any questions you have regarding this drug. Bupropion is available as over 50 Brand names in the US, therefore, there are many formulations.
Seizure Risk – Important Information
For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider right away about any side effects that bother you. If you have trouble sleeping, do not take your medicine too close to bedtime. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. If you have any of the above symptoms of mania, call your healthcare provider.
What are the most common side effects of bupropion?
- The estimated background risk for major birth defects and miscarriage is unknown for the indicated population.
- It is important for you to follow-up with your healthcare provider until your symptoms go away.
- False-positive urine immunoassay screening tests for amphetamines have been reported in patients taking bupropion.
- Bupropion is in a class of medications called antidepressants.
CNS toxicity has been reported when bupropion was coadministered with levodopa or amantadine. Adverse reactions have included restlessness, agitation, tremor, ataxia, gait disturbance, vertigo, and dizziness. It is presumed that the toxicity results from cumulative dopamine agonist effects. Use caution when administering WELLBUTRIN concomitantly with these drugs. Use extreme caution when coadministering WELLBUTRIN with other drugs that lower seizure threshold (e.g., other bupropion products, antipsychotics, antidepressants, theophylline, or systemic corticosteroids).
- Your blood pressure might get too high while you are using this medicine.
- Pre-existing glaucoma is almost always open-angle glaucoma because angle-closure glaucoma, when diagnosed, can be treated definitively with iridectomy.
- If you’re considering taking it, it’s important to learn what it is, how it works, pros and cons, side effects, dosage information, and more.
- If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
You can take Wellbutrin with or without food, but you should avoid alcohol as it can increase the risk of seizures or other side effects. In a second healthy volunteer trial, ritonavir at a dose of 600 mg twice daily decreased the AUC and the Cmax wellbutrin uses, dosage, side effects of bupropion by 66% and 62%, respectively. The exposure of the hydroxybupropion metabolite was decreased by 78%, the threohydrobupropion decreased by 50%, and the erythrohydrobupropion decreased by 68%.
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Counsel patients to notify their healthcare provider if they are taking or plan to take any prescription or over-the-counter drugs because WELLBUTRIN and other drugs may affect each other’s metabolisms. Advise patients that any CNS-active drug like WELLBUTRIN may impair their ability to perform tasks requiring judgment or motor and cognitive skills. Advise patients that until they are reasonably certain that WELLBUTRIN does not adversely affect their performance, they should refrain from driving an automobile or operating complex, hazardous machinery. The pupillary dilation that occurs following use of many antidepressant drugs including WELLBUTRIN may trigger an angle-closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy. The following adverse reactions have been identified during postapproval use of WELLBUTRIN and are not described elsewhere in the label. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
The risk appears to be increased in patients with bipolar disorder or who have risk factors for bipolar disorder. Prior to initiating WELLBUTRIN, screen patients for a history of bipolar disorder and the presence of risk factors for bipolar disorder (e.g., family history of bipolar disorder, suicide, or depression). WELLBUTRIN is not approved for use in treating bipolar depression.
Serious skin reactions (eg, Stevens-Johnson syndrome) can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with this medicine. Bupropion may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed.
Some other medicines may alter the blood levels of bupropion, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. Bupropion may cause false-positive results on certain urine drug screenings for amphetamines. Tell all of your healthcare providers about the medicines you take. Bupropion may increase your blood pressure or make it worse if you have a history of high blood pressure.
If you think bupropion is right for you, reach out to a qualified mental health care provider for an assessment and customized treatment plan. No, Wellbutrin isn’t an SSRI or selective serotonins reuptake inhibitor. Both of these types of medications work on similar neurotransmitters but they work in slightly different ways. Additionally, bupropion has been shown to increase energy and reduce fatigue while having fewer sexual side effects than SSRIs. In some cases, bupropion can cause a decrease in appetite, leading to weight loss, which can have serious health benefits for individuals who are overweight or obese. When bupropion is used for smoking cessation under the name brand Zyban, individuals should plan to stop smoking completely by the second week of use and may use a nicotine product such as a patch to aid withdrawal symptoms.
The chance of having seizures increases with higher doses of WELLBUTRIN. For more information, see the sections “Who should not take WELLBUTRIN? ” and “What should I tell my healthcare provider before taking WELLBUTRIN? ” Tell your healthcare provider about all of your medical conditions and all the medicines you take. Do not take any other medicines while you are taking WELLBUTRIN unless your healthcare provider has said it is okay to take them. If you have a seizure while taking WELLBUTRIN, stop taking the tablets and call your healthcare provider right away.
It is also used as part of a support program to help people stop smoking. Just like physical health, everyone’s mental health needs are different and, sometimes, the path to mental wellness includes medications. Fortunately, there are numerous safe medications that work in direct and targeted ways to restore joy and stability to your life, and one of those is Wellbutrin, a common medication for depression and SAD. In one study, there was no difference between bupropion and other antidepressants in the occurrence of birth defects. Bupropion should only be used in pregnancy if the benefit outweighs the potential risk. Neither form of Wellbutrin is FDA approved for weight loss or anxiety at this time.
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